The story revolves around a young man, Kyrie, who possesses the power to destroy the world, though he does not know why. The female lead is Morte, a member of a group that is trying to destroy the world.
An anime adaptation, also titled Sands of Destruction was produced by Production I.G and directed by Shunsuke Tada. It began broadcasting on TV Tokyo on July 7, 2008 and ended on September 30, 2008, spawning 13 episodes. It features an opening theme titled "ZERØ" and sung by AAA, and an ending theme titled "Kaze no Kioku: To the End of the World" (風の記憶 〜to the end of the world〜?, lit. "Memory of Wind 〜to the end of the world〜") sung by Aimmy. The series features only a single season of 13 episodes. It was licensed by Funimation Entertainment for a North American release, and the DVD set was released in 2010.